Clinically-relevant Germline Variants in Children with Non-Medullary Thyroid Cancer

CONCLUSION: The reported prevalence (13%) of germline variants in well-known tumor predisposing genes and the added value of a revised personal-/family history and histology led us to recommend genetic counseling for all childhood NMTC patients.The detected tumor predisposition syndromes are associated with a risk for second cancers which necessitates additional surveillance of the index patients and pre-symptomatic genetic testing of at risk family members.PMID:38415346 | DOI:10.1210/clinem/dgae107

Source: The Journal of Clinical Endocrinology and Metabolism - February 28, 2024 Category: Endocrinology Authors: Karin van der Tuin Dina Ruano Jeroen Knijnenburg Rob B van der Luijt Hans Morreau Thera P Links Frederik J Hes Dutch Pediatric Thyroid cancer consortium Source Type: research