miRNA-192-5p targets Dyrk1a to attenuate cerebral injury in MCAO mice by suppressing neuronal apoptosis and neuroinflammation

CONCLUSIONS: We found that intracerebroventricular administration of miRNA-192-5p before MCAO attenuatedacute cerebral injury by suppressing neuronal apoptosis and neuroinflammation in mice, and these protective effects might be mediated by downregulation of Dyrk1a. This study would help identify novel therapeutic targets for IS.PMID:38258843 | DOI:10.5603/fhc.96703

Source: Folia Histochemica et Cytobiologica - January 23, 2024 Category: Cytology Authors: Wei He De-Long Meng Dan Yang Qing-You Chen Li Li Li-Hua Wang Source Type: research