NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7

Conclusions: Molecular switch from NOX1 to NOX2 in colon cancer cells induces ROS production and subsequently enhances MMP-7 expression by deactivating AMPK, which otherwise inhibits stimulus-induced autoregulation of ROS and NOX2 gene expression.

http://www.molecular-cancer.com/content/14/1/123

Source: Molecular Cancer - June 27, 2015 Category: Cancer & Oncology Authors: Suhrid BanskotaSushil RegmiJung-Ae Kim Source Type: research