Acute sickle cell hepatopathy: A case report and literature review

J Natl Med Assoc. 2023 Oct 4:S0027-9684(23)00111-6. doi: 10.1016/j.jnma.2023.09.013. Online ahead of print.ABSTRACTSickle cell disease (SCD) is an inherited hemoglobinopathy with protean clinical manifestations. The liver could be affected by various SCD-associated complications of an overlapping nature. The clinical presentations of "sickle cell hepatopathy" range from clinically asymptomatic patients to those with life-threatening complications. Herein we report an SCD patient who presented with right upper quadrant abdominal pain and jaundice, eventually diagnosed as a self-limited form of acute sickle cell hepatopathy with overlapping features of acute hepatic crisis and benign intrahepatic cholestasis. Using this patient as an illustration, we will review the spectrum of hepatobiliary presentations in the SCD population.PMID:38383222 | DOI:10.1016/j.jnma.2023.09.013

Source: Journal of the National Medical Association - February 21, 2024 Category: General Medicine Authors: Morteza Hassanzadeh Zahra Momayez Sanat Somayeh Khayatian Mohammadjavad Sotoudeheian Amirmasoud Shahbazian SeyedAhmad Hoseini Source Type: research