Systemic oxidative stress may be associated with reduced IgG antibody titers against SARS-cov-2 in vaccinated kidney transplant recipients: A post-hoc analysis of the RECOVAC-IR observational study

CONCLUSIONS: KTR show suboptimal serological responses to SARS-CoV-2 vaccination, which is inversely associated with serum R-SH, reflecting systemic oxidative stress. Albeit this association was not robust to relevant confounding factors, it may at least partially be involved in the inability of KTR to generate a positive serological response after SARS-CoV-2 vaccination.PMID:38395091 | DOI:10.1016/j.freeradbiomed.2024.02.018

Source: Free Radical Biology and Medicine - February 23, 2024 Category: Biology Authors: Larissa E van Eijk Arno R Bourgonje A Lianne Messchendorp Marian L C Bulthuis Marjan Reinders-Luinge Berber Doornbos-van der Meer Johanna Westra Wilfred F A den Dunnen Jan-Luuk Hillebrands Jan-Stephan F Sanders Harry van Goor RECOVAC Collaborators Source Type: research