Weight loss induced by a hypocaloric diet with or without fish oil supplementation re-established iron and omega-3 fatty acid homeostasis in middle-aged women with obesity: A post-hoc analysis of a randomized controlled trial

Obesity and iron-deficiency (ID) anemia (IDA) remain major global health concerns. The pathophysiology of obesity-related functional ID has linked adiposity-mediated inflammation to dysregulated iron metabolism [1]. Hepcidin-ferroportin interaction regulates iron homeostasis [2]. However, inflammation triggers an elevation in hepcidin levels, which results in a reduction of bioavailable iron, thereby impacting the support of erythropoiesis [3,4]. Consequently, patients with obesity and chronic disease may develop IDA and tissue iron overload [5].
Source: Maturitas - Category: Primary Care Authors: Tags: Original article Source Type: research