Huntington's disease prevalence in Asia: a systematic review and meta-analysis

CONCLUSION: Our study reveals that HD disease affects the population of Asia to a lesser extent than in Europe. The plausible explanation for differences in prevalence is that in some countries, the affected individuals will not self-refer to HD screening for fear of social stigma, negative influence in marriage, and lack of genetic and neurological testing. Another explanation is that studies that used genetic testing exclusively were able to identify the CAG repeats, subgroups of CAG repeat A1 & A2, and haplogroup C, which has less predisposition to high HD prevalence in Asians compared to the Caucasian population.PMID:38362783 | DOI:10.1708/4205.41943
Source: Rivista di Psichiatria - Category: Psychiatry Authors: Source Type: research