Silencing Apoe with divalent-siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease

DISCUSSION: These results establish siRNA-based modulation of Apoe as a viable therapeutic approach, highlight immune activation as a key pathway affected by Apoe modulation, and provide the technology to further evaluate the impact of APOE silencing on neurodegeneration.PMID:38375983 | DOI:10.1002/alz.13703

Source: The Journal of Alzheimers Association - February 20, 2024 Category: Psychiatry Authors: Chantal M Ferguson Samuel Hildebrand Bruno M D C Godinho Julianna Buchwald Dimas Echeverria Andrew Coles Anastasia Grigorenko Lorenc Vangjeli Jacquelyn Sousa Nicholas McHugh Matthew Hassler Francesco Santarelli Michael T Heneka Evgeny Rogaev Anastasia Khv Source Type: research