IRF1 deficiency predisposes cartilage to accumulate DNA damage and promotes osteoarthritis development

ConclusionIRF1 offers DNA damage surveillance in chondrocytes, protecting them from oxidative stress associated with OA risk factors. Our study provides a crucial and cautionary perspective that compromising IRF1 activity renders chondrocytes vulnerable to cellular senescence and promotes OA development.

Source: Arthritis and Rheumatology - January 25, 2024 Category: Rheumatology Authors: Yongsik Cho, Hyeonkyeong Kim, Geunho Yook, Sangmin Yong, Soy Kim, Narae Lee, Yi ‐Jun Kim, Jin‐Hee Kim, Tae Woo Kim, Moon Jong Chang, Kyoung Min Lee, Chong Bum Chang, Seung‐Baik Kang, Jin‐Hong Kim Tags: Full Length Source Type: research