Calcium/calcimimetic < em > via < /em > calcium-sensing receptor ameliorates cholera toxin-induced secretory diarrhea in mice

CONCLUSION: Treatment of acute secretory diarrheas remains a global challenge. Despite advances in diarrhea research, few have been made in the realm of diarrhea therapeutics. ORS therapy has remained the standard of care, although it does not halt the losses of intestinal fluid and ions caused by pathogens. There is no cost-effective therapeutic for diarrhea. This and other studies suggest that adding calcium to ORS or using calcimimetics to activate intestinal CaSR might represent a novel approach for treating secretory diarrheal diseases.PMID:38314127 | PMC:PMC10835527 | DOI:10.3748/wjg.v30.i3.268
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Source Type: research