Transcellular Barriers to Glucose Delivery in the Body

We present the most up-to-date knowledge on glucose handling by the gut, liver, brain endothelium, and kidney, and discuss underlying molecular mechanisms and open questions. Diseases associated with defects in glucose delivery and homeostasis are also briefly addressed. We propose that the universal problem of sparing glucose from catabolism in favor of translocation across the barriers posed by epithelia and endothelia is resolved through common mechanisms involving glucose transfer to the endoplasmic reticulum, from where glucose exits the cells via unconventional cellular mechanisms.PMID:38345907 | DOI:10.1146/annurev-physiol-042022-031657

Source: Physiological Reviews - February 12, 2024 Category: Physiology Authors: Amira Klip Katrien De Bock Philip J Bilan Erik A Richter Source Type: research