Antioxidant and Anti-Arthritic Activity of Bombax buonopozense P. Beauv. Leaves

CONCLUSION: Phytochemical screening revealed the presence of flavonoids, alkaloids, and phenolics. The brine shrimp lethality assay of the crude extract and fractions gave LC50 value ≥ 1000 µg/mL, compared to Cyclophosphamide (LC50 = 224.7±0.35µg/mL). The BBME had TPC value of 19.8±0.56 mg GAE/g, while the TFC of ethyl acetate fraction was the highest (173.5±0.05 mg QE/g). The ethyl acetate fraction has the highest antioxidant activity (IC50 = 20.96±0.23 µg/mL) as compared to ascorbic acid (2.8±0.01) and rutin (20.6±9.26 µg/mL). BBME significantly reduced the paw circumference. BBME (400 mg/kg) prevented biochemical changes to a greater extent than Celecoxib (20 mg/kg). Bombax buonopozense leaves could be an effective antiarthritic and holds prospect in the treatment of rheumatoid arthritis.PMID:38367936 | DOI:10.1016/j.pharma.2024.02.008

Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Olusoji Aanuoluwa Fadogba Akingbolabo Daniel Ogunlakin Abayomi Mayowa Ajayi Mubo Adeola Sonibare Source Type: research