GPX3 supports ovarian cancer tumor progression in vivo and promotes expression of GDF15

CONCLUSIONS: We show for the first time that tumor produced GPX3 is necessary for ovarian cancer growth in vivo and that it regulates expression of GDF15. The immune profile associated with GPX3 expression in serous ovarian tumors suggests that GPX3 may be an alternate marker of ovarian tumors susceptible to immune check-point inhibitors.PMID:38342006 | DOI:10.1016/j.ygyno.2024.02.004

Source: Gynecologic Oncology - February 11, 2024 Category: Cancer & Oncology Authors: Caroline Chang Ya-Yun Cheng Shriya Kamlapurkar Sierra White Priscilla W Tang Amal T Elhaw Zaineb Javed Katherine M Aird Karthikeyan Mythreye R ébécca Phaëton Nadine Hempel Source Type: research