Cancer stem cells: Recent trends in cancer therapy

Nucleosides Nucleotides Nucleic Acids. 2024 Feb 6:1-32. doi: 10.1080/15257770.2024.2311789. Online ahead of print.ABSTRACTCancer stem cells (CSCs) are a subset of tumor cells that were first identified in blood cancers (leukemia) and are considered promising therapeutic targets in cancer treatment. These cells are the cause of many malignancies including metastasis, heterogeneity, drug resistance, and tumor recurrence. They carry out these activities through multiple transcriptional programs and signaling pathways. This review summarizes the characteristics of cancer stem cells, explains their key signaling pathways and factors, and discusses targeted therapies for cancer stem cells. Investigating these mechanisms and signaling pathways responsible for treatment failure may help identify new therapeutic pathways in cancer.PMID:38319997 | DOI:10.1080/15257770.2024.2311789
Source: Nucleosides, Nucleotides and Nucleic Acids - Category: Biochemistry Authors: Source Type: research