Overexpression of EphB2 in the basolateral amygdala is crucial for inducing visceral pain sensitization in rats subjected to water avoidance stress

CONCLUSIONS: Taken together, the results suggest that EphB2 in BLA plays an essential role in inducing visceral hypersensitivity. In the maintenance stage, the involvement of EphB2 is crucial but not sufficient. The increase in EphB2 induced by WAS may enhance synaptic plasticity in BLA through upregulating NMDARs, which results in IBS-like symptoms. These findings may give insight into the treatment of IBS and related psychological distress.PMID:38353051 | PMC:PMC10865153 | DOI:10.1111/cns.14611

Source: CNS Neuroscience and Therapeutics - February 14, 2024 Category: Neuroscience Authors: Guang-Bing Duan Jun-Wen Wang Hui-Hui Sun Zhi-Yu Dong Yan Zhang Zhen-Xiang Wang Ye Chen Ying Chen Ying Huang Shu-Chang Xu Source Type: research