NR5A2 promotes malignancy progression and mediates the effect of cisplatin in cutaneous squamous cell carcinoma

ConclusionNR5A2 plays a crucial role in the progression of cSCC, and the Wnt/ β-catenin signaling pathway may be involved in the regulation of NR5A2-mediated cSCC. Knockdown of NR5A2 enhanced both the proliferation inhibiting and apoptosis promoting effects of cisplatin on cSCC.

Source: Immunity, Inflammation and Disease - February 16, 2024 Category: Allergy & Immunology Authors: Wang Ye, Cao Ya ‐xuan, Tang Shan‐shan, Long Qiu, Ma Ting, Chen Shao‐jie, Cao Yu Tags: ORIGINAL ARTICLE Source Type: research