Elaborate cooperation of poly(rC)-binding proteins 1/2 and glutathione in ferroptosis induced by plasma-activated Ringer's lactate

In conclusion, PAL can selectively sensitize MM cells to ferroptosis by remodeling cytoplasmic iron homeostasis, where glutathione and PCBPs play distinct roles, resulting in lethal ferritinophagy and mitochondrial dysfunction. Our findings indicate the clinical application of PAL as a ferroptosis-inducer and the potential of PCBPs as novel targets in cancer therapeutics.PMID:38325565 | DOI:10.1016/j.freeradbiomed.2024.02.001

Source: Free Radical Biology and Medicine - February 7, 2024 Category: Biology Authors: Li Jiang Hao Zheng Moe Ishida Qinying Lyu Shinya Akatsuka Yashiro Motooka Kotaro Sato Yoshitaka Sekido Kae Nakamura Hiromasa Tanaka Kenji Ishikawa Hiroaki Kajiyama Masaaki Mizuno Masaru Hori Shinya Toyokuni Source Type: research