Cytotoxic effects of kinetin riboside and its selected analogues on cancer cell lines

Bioorg Med Chem Lett. 2024 Jan 25;100:129628. doi: 10.1016/j.bmcl.2024.129628. Online ahead of print.ABSTRACTN6-[(Furan-2-yl)methyl]adenosine (kinetin riboside) and its seven synthesized analogues were examined for the ability to inhibit the growth of five human carcinoma cell lines and for comparison of normal human lung fibroblast cell line (MRC-5). Out of the compounds evaluated, 8-azakinetin riboside was shown to exhibit significant cytotoxic activity for 72 h treatment against ovarian OVCAR-3 and pancreatic MIA PaCa-2 cancer cells (IC50 = 1.1 μM) with an observed weaker effect against MRC-5 cells (IC50 = 4.6 μM). Kinetin riboside, as well as its N6-[(furan-3-yl)methyl]- and N6-[(thien-2-yl)methyl]- counterparts, also exhibited cytotoxic activities at low micromolar levels but were non-selective over MRC-5 cells.PMID:38280656 | DOI:10.1016/j.bmcl.2024.129628
Source: Bioorganic and Medicinal Chemistry Letters - Category: Chemistry Authors: Source Type: research