Recent insights into the control of mitochondrial fission

Biochem Soc Trans. 2024 Jan 30:BST20230220. doi: 10.1042/BST20230220. Online ahead of print.ABSTRACTMitochondria are the powerhouse of the cell. They undergo fission and fusion to maintain cellular homeostasis. In this review, we explore the intricate regulation of mitochondrial fission at various levels, including the protein level, the post-translational modification level, and the organelle level. Malfunctions in mitochondrial fission can have detrimental effects on cells. Therefore, we also examine the association between mitochondrial fission with diseases such as breast cancer and cardiovascular disorders. We anticipate that a comprehensive investigation into the control of mitochondrial fission will pave the way for the development of innovative therapeutic strategies.PMID:38288744 | DOI:10.1042/BST20230220

Source: Biochemical Society Transactions - January 30, 2024 Category: Biochemistry Authors: Jiajia He Ke Liu Chuanhai Fu Source Type: research