Bufalin reprograms erythrocyte lifespan through p38 MAPK and Rac1 GTPase

In conclusion, BFN elicits premature RBC death, subject to regulation by p38 MAPK and Rac1 GTPase, and is detrimental to other peripheral blood cells. Altogether, these novel findings prompt cautious consideration of the toxin in anticancer therapy.PMID:38316294 | DOI:10.1016/j.toxicon.2024.107636
Source: Toxicon - Category: Toxicology Authors: Source Type: research