An unusual manifestation of Langerhans cell histiocytosis in the gastrointestinal tract

We present the case of a 49-year-old woman with a previous diagnosis of LCH in 2018 with only cutaneous involvement, managed with topical corticosteroids. After developing hypertransaminasemia, a PET-CT scan was performed, showing dissemination of the disease with bone, hepatosplenic and gynecological involvement. In addition, hypermetabolic lesions were described in the cecum with ileocecal adenopathies. A colonoscopy was performed showing in the cecum and ascending colon multiple sessile polyps of 5-10mm with central fibrin-coated erosions, from which biopsies were obtained. Histology revealed typical features of LCH with positive staining for CD1A, S100 and Langerin.PMID:38284911 | DOI:10.17235/reed.2024.10152/2023
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Authors: Source Type: research