Molecular Phenotypes of ARDS in the ROSE Trial have Differential Outcomes and Gene Expression Patterns That Differ at Baseline and Longitudinally Over Time

CONCLUSIONS: The Hyperinflammatory and Hypoinflammatory phenotypes have different clinical, protein, and dynamic transcriptional characteristics. These findings support the clinical and biological potential of molecular phenotypes to advance precision care in ARDS.PMID:38345571 | DOI:10.1164/rccm.202308-1490OC

Source: Am J Respir Crit Car... - February 12, 2024 Category: Intensive Care Authors: Pratik Sinha Lucile Neyton Aartik Sarma Nelson Wu Chayse Jones Hanjing Zhuo Kathleen D Liu Estella Sanchez Guerrero Rajani Ghale Christina Love Eran Mick Kevin L Delucchi Charles R Langelier B Taylor Thompson Michael A Matthay Carolyn S Calfee NHLBI PETAL Source Type: research