Anti-inflammatory effects of infliximab and methotrexate on peripheral blood and synovial fluid mononuclear cells: ex vivo study

CONCLUSION: Both IFX and MTX effectively inhibited PBMC proliferation and IFN-γ production, but only IFX reduced synovial monocytes and pro-inflammatory gene expression in SFMCs, suggesting a differential impact of IFX and MTX on critical inflammatory cell populations ex vivo.PMID:38275170 | DOI:10.1080/03009742.2023.2300887

Source: Scandinavian Journal of Rheumatology - January 26, 2024 Category: Rheumatology Authors: S Gertel M Rokach A Polachek I Litinsky M Anouk O Elkayam V Furer Source Type: research