Activating astrocytic α2A adrenoceptors in hippocampus reduces glutamate toxicity to attenuate sepsis-associated encephalopathy in mice

CONCLUSIONS: Our results suggest that neurocognitive protection against SAE after hippocampal α2A-AR activation is astrocyte specific. This protection may involve the inhibition of astrocyte reactivity and alleviation of glutamate neurotoxicity, thereby reducing synaptic injury. The cAMP/protein kinase A (PKA) signaling pathway is a potential cellular mechanism by which activating α2A-AR modulates astrocytic function.PMID:38320682 | DOI:10.1016/j.bbi.2024.02.005

Source: Brain, Behavior, and Immunity - February 6, 2024 Category: Neurology Authors: Bin Mei Xiaoxia Xu Juntao Weng Yueyue Yang Peng Wang Gaolin Qiu Chi Zhang Qunlin Zhang Yao Lu Xuesheng Liu Source Type: research