Bidirectional two-sample Mendelian randomization study of differential white blood cell counts and schizophrenia

CONCLUSION: This MR study utilised multiple MR methods to obtain results suggesting bidirectional genetic genetically-predicted relationships for elevated lymphocyte counts and schizophrenia risk. In addition, moderate evidence also showed bidirectional genetically-predicted relationships between schizophrenia and monocyte counts, and unidirectional effect from genetic liability for eosinophil count to schizophrenia and from genetic liability for schizophrenia to neutrophil count. The influence of schizophrenia to eosinophil count is less certain. Our findings support the role of WBC in schizophrenia and concur with the hypothesis of neuroinflammation in schizophrenia.PMID:38355025 | DOI:10.1016/j.bbi.2024.02.015

Source: Brain, Behavior, and Immunity - February 14, 2024 Category: Neurology Authors: Perry B M Leung Zipeng Liu Yuanxin Zhong Justin D Tubbs Marta Di Forti Robin M Murray Hon- Cheong So Pak C Sham Simon S Y Lui Source Type: research