Strategies to Overcome Antimicrobial Resistance in Nosocomial Infections, A Review and Update

Infect Disord Drug Targets. 2024 Jan 26. doi: 10.2174/0118715265276529231214105423. Online ahead of print.ABSTRACTNosocomial infections, also known as healthcare-associated infections, are a signif-icant global concern due to their strong association with high mortality and morbidity in both developed and developing countries. These infections are caused by a variety of pathogens, particularly the ESKAPE group of bacteria, which includes the six pathogens Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudo-monas aeruginosa, and Enterobacter spp. These bacteria have demonstrated noteworthy re-sistance to different antibiotics. Antimicrobial resistance mechanisms can manifest in various forms, including restricting drug uptake, modifying drug targets, inactivating drugs, active drug efflux, and biofilm formation. Accordingly, various strategies have been developed to combat antibiotic-resistant bacteria. These strategies encompass the development of new antibiotics, the utilization of bacterio-phages that specifically target these bacteria, antimicrobial combination therapy and the use of peptides or enzymes that target the genomes or essential proteins of resistant bacteria. Among promising approaches to overcome antibiotic resistance, the CRISPR/Cas system stands out and offers many advantages. This system enables precise and efficient editing of genetic material at specific locations in the genome. Functioning as a bacterial "a...
Source: Infectious Disorders Drug Targets - Category: Infectious Diseases Authors: Source Type: research