Uncommon Protein-Coding Variants Associated With Suicide Attempt in a Diverse Sample of U.S. Army Soldiers

Suicide is a societal and public health concern of global scale. Identifying genetic risk factors for suicide attempt can characterize underlying biology and enable early interventions to prevent deaths. Recent studies have described common genetic variants for suicide-related behaviors. Here, we advance this search for genetic risk by analyzing the association between suicide attempt and uncommon variation exome-wide in a large, ancestrally diverse sample.

Source: Biological Psychiatry - December 21, 2023 Category: Psychiatry Authors: Matthew D. Wilkerson, Daniel Hupalo, Joshua C. Gray, Xijun Zhang, Jiawei Wang, Matthew J. Girgenti, Camille Alba, Gauthaman Sukumar, Nathaniel M. Lott, James A. Naifeh, Pablo Aliaga, Ronald C. Kessler, Clesson Turner, Harvey B. Pollard, Clifton L. Dalgard Tags: Archival Report Source Type: research