Dual-release hydrocortisone improves body composition and the glucometabolic profile in patients with secondary adrenal insufficiency

ConclusionThis study suggests that switching to DR-HC leads to lower late-evening cortisol/cortisone exposure and a more favourable metabolic profile and body composition. In contrast, decreased osteocalcin with increasing sclerostin might indicate a negative impact on bones.Clinical trial registrationEudraCT201400203932
Source: Endocrine - Category: Endocrinology Source Type: research