Excellent Outcomes Using a Non-Myeloablative Conditioning with Thiotepa and Post -Transplant Cyclophosphamide in Adults Undergoing a Matched Related Donor Bone Marrow Transplant for Severe Sickle Cell Disease

Allogeneic hematopoietic stem-cell transplantation (HSCT) is a validated curative therapy for sickle cell disease (SCD). The excellent outcomes of matched related donor (MRD) HSCT over the last 3 decades confirm the role of HLA-identical sibling BMT for SCD (PMID: 27965196). However, event-free survival (EFS) was lower with increasing age at transplantation (P

Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Reem Alasbali, Mohsen Alzahrani, Saud Alhayli, Walid K. Rasheed, Karina Wilkerson, Riad El Fakih, Bader AlAhmari, Hadeel Samarkandi, Abdulwahab Albabtain, Ahmad Alotaibi, Syed O Ahmed, Ayman Saad, Hazzaa Alzahrani, Fahad Almohareb, Mahmoud Aljurf, Adetola Tags: 62 Source Type: research