Single Center Evaluation of Patients with Therapy and Prior-Malignancy Related Acute Lymphoblastic Leukemia and the Use of Hematopoietic Stem Cell Transplants

Therapy-related (t-ALL) and previous malignancy-related acute lymphoblastic leukemia (pm-ALL) are a subset of ALL that arise after treatment of prior malignancy. Recent reports indicate that allogeneic hematopoietic stem cell transplantation (HCT) may yield comparable outcomes in t-ALL when compared to pm-ALL, however data remains limited in both diagnostic criteria and highest risk factors for worse prognosis. This single-center analysis aims to shed light on the unique behavior of t-ALL and pm-ALL with and without HCT.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 141 Source Type: research