Long-Term Outcomes of Autologous Stem Cell Transplant with Thiotepa, Busulfan, and Cyclophosphamide Conditioning for Patients with Central Nervous System Lymphoma

Central nervous system lymphoma (CNSL) is associated with dismal outcomes and short survival. Treatment of CNSL involves high-dose chemotherapy followed by consolidative autologous stem cell transplant (ASCT). Thiotepa, busulfan and cyclophosphamide (TBC) conditioning improves progression-free survival in CNSL, but further data is needed to evaluate long-term toxicity and survival outcomes. We hereby report our experience in patients with primary and secondary CNSL who received TBC conditioning for ASCT.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 207 Source Type: research