Periostin in Cancer-Associated Fibroblasts Promotes Esophageal Squamous Cell Carcinoma Progression by Enhancing Cancer and Stromal Cell Migration

Cancer-associated fibroblasts (CAFs) in the tumor microenvironment are involved in the progression of various cancers, including esophageal squamous cell carcinoma (ESCC). CAF-like cells were generated through direct co-culture of human bone marrow-derived mesenchymal stem cells (MSCs), one of CAF origins, with ESCC cells, and periostin was found to be highly expressed in CAF-like cells. After direct co-culture, ESCC cells showed increased malignant phenotypes such as survival, growth, and migration, as well as increased phosphorylation of Akt and Erk.

Source: American Journal of Pathology - February 4, 2024 Category: Pathology Authors: Shoji Miyako, Yu-ichiro Koma, Takashi Nakanishi, Shuichi Tsukamoto, Keitaro Yamanaka, Nobuaki Ishihara, Yuki Azumi, Satoshi Urakami, Masaki Shimizu, Takayuki Kodama, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki Tags: Regular Article Source Type: research