Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time –kill experiments: agreement with in silico predictions

ConclusionsPolymyxin B and minocycline in combination showed synergistic effects, mainly against the KPC-3-producingK. pneumoniae. The agreement between the experimental results andin silico predictions supports the use of PK/PD models based on static time –kill data to predict the activity of antibiotic combinations at dynamic drug concentrations.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research