Gamma Knife radiosurgery for central neurocytoma: a quantitative systematic review and metanalysis

This study aimed to systematically review the available knowledge regarding GKRS for CN. A systematic investigation of the scientific literature was undertaken through an exhaustive search across prominent databases, including PubMed, Web of Science, and Google Scholar, by employing precise MeSH terms such as “Central neurocytoma,” “Radiosurgery,” “Gamma Knife,” and “Stereotactic Radiosurgery.” A comprehensive quantitative systematic review and meta-analysis were meticulously conducted, focusing on cases of CN treated with GKRS for a thorough evaluation of outcomes and efficacy. Seventeen articles, including 289 patients, met the inclusion criteria. Random effects meta-analysis estimates for disease control and local tumor control were 90% (95% CI 87–93%;I2  = 0%,p <  0.74) and 94% (95% CI 92–97%;I2  = 0%,p <  0.98), respectively. When considering only studies with at least 5 years of follow-up, progression-free survival was 89% (95% CI 85–94%;I2  = 0.03%,p <  0.74). The mean clinical control rate was 96%. This systematic review and meta-analysis confirmed the safety and efficacy of GKRS in managing CN.
Source: Neurosurgical Review - Category: Neurosurgery Source Type: research