Exhaled breath is found to be better than blood samples for determining propofol concentrations in the brain tissues of rats

In this study, we measured CE, CP, and CB in mechanically ventilated rats injected with propofol. Exhaled breath samples from the rats were collected every 20 s and analyzed using our team ’s developed vacuum ultraviolet time-of-flight mass spectrometry. Additionally, femoral artery blood samples and brain tissue samples at different time points were collected and measured using high-performance liquid chromatography mass spectrometry. The results demonstrated that propofol concentr ation in exhaled breath exhibited stronger correlations with that in brain tissues compared to plasma levels, suggesting its potential suitability for reflecting anesthetic action sites’ concentrations and anesthesia titration. Our study provides valuable animal data supporting future clinical app lications.
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Source Type: research