Highlights from the literature

Langerhans cell histiocytosis (LCH) It’s rare, but it is there, and will need to be considered in your differential diagnoses on a few occasions in a general paediatrician’s career. Lucina’s most recent experience has been with the common presentation of polydipsia and polyuria and an ultimate diagnosis of central diabetes insipidus (CDI) caused by LCH. Alexander A and Zacharin M [J Paediatr and Child Health 2023 https://doi.org/10.1111/jpc.16521] have documented the incidence of endocrine features in paediatric patients with LCH from one tertiary endocrine centre in Victoria, Australia. Using a simple retrospective chart review of electronic medical records and oncology database of patients with biopsy diagnosed LCH, they identified one hundred seventy-one patients diagnosed with LCH over a 30 year period. Mean age at diagnosis was 5 years 8 months. Of these, 15% (n = 21) had CDI, 7% had growth hormone deficiency (GHD) (n = 10) and 8% (n = 11) had more than one...
Source: Archives of Disease in Childhood - Category: Pediatrics Tags: Miscellanea Source Type: research