Regenerative Neurogenesis After Ischemic Stroke Promoted by Nicotinamide Phosphoribosyltransferase-Nicotinamide Adenine Dinucleotide Cascade [Basic Sciences]

Conclusions— Our data demonstrate that the Nampt–NAD cascade may act as a centralizing switch in postischemic regeneration through controlling different sirtuins and therefore represent a promising therapeutic target for long-term recovery of ischemic stroke.

http://stroke.ahajournals.org/cgi/content/short/46/7/1966?rss=1

Source: Stroke - June 22, 2015 Category: Neurology Authors: Zhao, Y., Guan, Y.-F., Zhou, X.-M., Li, G.-Q., Li, Z.-Y., Zhou, C.-C., Wang, P., Miao, C.-Y. Tags: Animal models of human disease, Brain Circulation and Metabolism Basic Sciences Source Type: research