Genetic and functional variants of the TBX20 gene promoter in dilated cardiomyopathy

ConclusionsThese data indicate that the DSV (g.4275G>T) and three SNPs [g.4949C>T (rs1191745927), g.5114G>A (rs112076877) and g.5252C>T (rs1356932911)] increase transcription activity ofTBX20 gene promoter in both HEK-293 and neonatal rat cardiomyocytes (NRCMs) cell lines by affecting the binding of transcription factors. But the mechanism remains to be verified in  vivo.

Source: Molecular Genetics & Genomic Medicine - January 18, 2024 Category: Genetics & Stem Cells Authors: Xue Gao, Shuchao Pang, Liangcai Ding, Han Yan, Yinghua Cui, Bo Yan Tags: ORIGINAL ARTICLE Source Type: research