Characterisation of T cell receptor repertoires in coeliac disease

Conclusions
Small intestinal TRB and TRG repertoires of patients with CD are more diverse than individuals without CD, likely due to mucosal recruitment and accumulation of T cells because of protracted inflammation. Enrichment of the unique TRG CDR3 AA sequence in the mucosa of patients with CD may suggest disease-associated changes in the TCR IE lymphocyte (IEL) landscape.

Source: Journal of Clinical Pathology - January 18, 2024 Category: Pathology Authors: Lee, L. W., Shafiani, S., Crossley, B., Emerson, R. O., Williamson, D., Bunin, A., Vargas, J., Han, A. S., Kaplan, I. M., Green, P. H. R., Kirsch, I., Bhagat, G. Tags: Open access Original research Source Type: research