The authors reply

In podocyte-specific calcium-sensing receptor knockout mice, we recently demonstrated a role of calcium-sensing receptor signaling in control of glomerular disease and the therapeutic potential of calcimimetics.1,2 Off-label therapy with cinacalcet together with oral calcium in 4 children with nephrotic syndrome was well tolerated, reduced proteinuria by up to 96%, and resolved edema. Early viral infection –related relapses, however, suggested that the effect of calcium-sensing receptor stimulation was counteracted by additional immunologic triggers.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research