Blood pressure response and symptoms during active standing test among hospitalized and outpatients with heart failure: results from the GRAVITY-HF prospective observational cohort study

Orthostatic hypotension (OH) and orthostatic hypertension (OHtn) characterize opposite forms of excessive blood pressure (BP) change during orthostatic stress. Regardless of the change directionality, both responses are common in general population with an average prevalence of 30%1 and independently associated with morbidity, all-cause mortality and major cardiovascular events, including a two-fold higher risk of incident heart failure (HF)2 –4. A number of mechanisms link the inability to maintain normotension at standing and HF including shared pathophysiology mediated by volume changes, autonomic dysregulation and limited cardiac reserve as well as common risk factors such as advanced age and chronic comorbidities5,6.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research