Deciphering climate resilience in Indian cattle breeds by selection signature analyses

In this study, we utilized Bovine 50  K chip data and four genome scan techniques to assess the genetic regions of positive selection for high-temperature adaptation. We have also performed a genome-wide investigation of genetic diversity, inbreeding, and effective population size in our target dataset. We identified potential regions for selection that are likely to be caused by adverse climatic conditions. We observed many adaptation genes in several potential selection signature areas. These include genes likeHSPB2,HSPB3,HSP20,HSP90AB1,HSF4,HSPA1B,CLPB,GAP43,MITF, and MCHR1 which have been reported in the cattle populations that live in varied climatic regions. The findings demonstrated that genes involved in disease resistance and thermotolerance were subjected to intense selection. The findings have implications for marker-assisted breeding, understanding the genetic landscape of climate-induced adaptation, putting breeding and  conservation programs into action.
Source: Tropical Animal Health and Production - Category: Veterinary Research Source Type: research