Impact of Istradefylline on Levodopa Dose Escalation in Parkinson ’s Disease: ISTRA ADJUST PD Study, a Multicenter, Open-Label, Randomized, Parallel-Group Controlled Study

ConclusionIST treatment reduced levodopa dose escalation in PD patients, resulting in less cumulative levodopa use. Adjunctive IST may improve motor function more objectively than increased levodopa dose in patients with PD.Trial RegistrationJapan Registry of Clinical Trials: jRCTs031180248.
Source: Neurology and Therapy - Category: Neurology Source Type: research