Identification of gene mutations associated with type 1 diabetes by next-generation sequencing in affected Palestinian families

Conclusion:IGF1R p.V579F and NEUROD1 p.P197H variants were associated with T1DM development in the two inflicted families. Further analysis and functional assays will be performed, including the generation of mutant model cell systems, to unravel their specific molecular mechanism in the disease development.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research