Breviscapine protects against pathological cardiac hypertrophy by targeting FOXO3a-mitofusin-1 mediated mitochondrial fusion

In conclusion, nuclear FOXO3a translocation induced by BRE presents a successful therapeutic avenue for addressing cardiac hypertrophy and HF through promoting MFN-1-dependent mitochondrial fusion.PMID:38190924 | DOI:10.1016/j.freeradbiomed.2024.01.007

Source: Free Radical Biology and Medicine - January 8, 2024 Category: Biology Authors: Xiaobing Lin Ming-Zhou Fei An-Xian Huang Liu Yang Ze-Jie Zeng Wen Gao Source Type: research