A comparison of clinical outcomes associated with dosing metronidazole every 8  hours versus every 12 hours: a systematic review and metaanalysis

CONCLUSIONS: This review suggests that dosing metronidazole every 12 hours is as effective as every-8-hour dosing for hospitalized patients with anaerobic infections. These encouraging findings would benefit from validation by a multicenter randomized controlled trial since there would be many benefits to a 12-hour dosing interval while achieving similar clinical outcomes with traditional dosing. The studies in this systematic review excluded patients with Clostridioides difficile and central nervous system and amebiasis infections, so the findings do not apply to these infection types.PMID:38174024 | PMC:PMC10761045 | DOI:10.1080/08998280.2023.2282144
Source: Baylor University Medical Center Proceedings - Category: Universities & Medical Training Authors: Source Type: research