The roles and mechanisms of TGFB1 in acute myeloid leukemia chemoresistance

This study concludes that TGFB1 level in R/R AML patients and drug-resistant strains is significantly increased. Blocking the TGFB signaling pathway can enhance the chemosensitivity of drug-resistant cells by suppressing SOX4 expression and metabolic reprogramming.PMID:38171389 | DOI:10.1016/j.cellsig.2023.111027

Source: Cellular Signalling - January 3, 2024 Category: Cytology Authors: Xue Liang Ji Zhou Cong Li Huiping Wang Yang Wan Chun Ling Lianfang Pu Wanqiu Zhang Mengmeng Fan Jingfang Hong Zhimin Zhai Source Type: research