NMNATs expression inhibition mediated NAD < sup > + < /sup > deficiency plays a critical role in doxorubicin-induced hepatotoxicity in mice

In conclusion, NAD+ deficiency due to NMNATs expression inhibition may attribute to the pathogenesis of DOX-induced hepatotoxicity, thus providing new insights for mitigating DOX side effects.PMID:38160893 | DOI:10.1016/j.taap.2023.116799

Source: Toxicology and Applied Pharmacology - December 31, 2023 Category: Toxicology Authors: Fang Cheng Yongtai Zhang Hongli Xiong Minzhu Zhao Qi Wang Ying Zhu Yongguo Li Renkuan Tang Jianbo Li Source Type: research