Differences in Oxygen-Induced Retinopathy Susceptibility Between Two Sprague Dawley Rat Vendors: A Comparison of Retinal Transcriptomes

CONCLUSION: Transcriptomic profiles differ substantially between rat pup retinas from Charles River Laboratories and Envigo at baseline and in response to oxygen-induced retinopathy, providing insight into vascular morphologic differences. Comparing transcriptomes identified new pathways for further research in oxygen-induced retinopathy pathogenesis and increased scientific rigor of this model.PMID:38152854 | DOI:10.1080/02713683.2023.2297346

Source: Current Eye Research - December 28, 2023 Category: Opthalmology Authors: Haeyeon Lee Mandkhai Molomjamts Heidi Roehrich Sydney Gudvangen Chanel Asuncion Michael K Georgieff Phu Tran Linda K McLoon Ellen C Ingolfsland Source Type: research