Ocular surface changes in mice with streptozotocin-induced diabetes and diabetic polyneuropathy

CONCLUSION: The early ocular changes in DM Mice only affect the lacrimal gland. Which, is reflected in the tear film composition of DPN mice. Due to the high protein concentration in tear fluid in humans, proteomic analysis in addition to noninvasive investigation of goblet cells and cornea can serve as a tools for the early diagnosis of DPN, DED in clinical practice. Early treatment could delay or even prevent the ocular complications of DM such as DED and PN.PMID:38141818 | DOI:10.1016/j.jtos.2023.12.006

Source: The Ocular Surface - December 23, 2023 Category: Opthalmology Authors: Martin Schicht Jessica Farger Saskia Wedel Marco Sisignano Klaus Scholich Gerd Geisslinger Natarajan Perumal Franz H Grus Swati Singh Afsun Sahin Friedrich Paulsen Elke L ütjen-Drecoll Source Type: research